Ultimate Spider-Man 153
Like the first issue of Avengers vs New Ultimates, this has a Death of Spider-Man banner; at least this comic has Spider-Man in it, and I suppose this story actually is the lead-in towards that death. Certainly the threat level is vast enough, since it involves some artefact with wishing powers, with no implied limits on it – maybe that level of danger will in due course drag in the big teams.